MASS SPECTROMETER

EXAMPLE APPLICATIONS

Bruker micrOTOF II

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Small molecule exact mass measurements

Bruker micrOTOF-Q II

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Electrospray MS coupled to ultra-high pressure LC for analysis of complex organic and aqueous materials and biological samples

Bruker Autoflex III

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Small and large molecules analysis; Peptide Mass Fingerprinting; peptide MS/MS

AB Sciex 6500 QTrap

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Multiple Reaction Monitoring (MRM) for quantitation; coupled to nano-LC for complex sample analysis (ex. lipids, metabolites, peptides)

Thermo Q Exactive
(Hummon Group)

 

Ultra-high resolution MS coupled to nano-ultra-high pressure LC for complex proteomic analysis

Thermo Velos Orbitrap 
(Dovichi Group)

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Ultra-high resolution MS coupled to nano-ultra-high pressure LC for complex proteomic analysis

Waters GCT Premier
 

Complex volatile mixture analysis

Waters TQD Acquity Triple Quadrupole
 

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Selective and quantitative analysis of small molecules, including metabolites.

 

INSTRUMENT

SPECIFICATIONS

GE Microcal Isothermal Titration Calorimeter ITC200
(Department of Chemistry and Biochemistry)

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  • Directly measure sub-millimolar to nanomolar binding constants
  • Requires as little as 10 ug of protein
  • Available temperatures of 2˚C to 80 ˚C

Jasco Circular Dichroism Spectrometer
(Department of Chemistry and Biochemistry)

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  • Operational in step-scan or continuous scan mode
  • Stopped-flow accessory available
  • Applications include protein folding studies and enzyme kinetics

Waters Alliance HPLC
 

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  • Coupled to a fraction collector